Hypervolemic short-time hemodilution: Longtime observation of hemorheological parameters

Article type: Research Article

Authors: Koltringer, P. | Eber, O. | Lind, P. | Klima, G. | Ribitsch, V.^{; *}

Affiliations: Hospital Barmherzige Brüder Graz-Eggenberg, Bergstraße 27, 8020 Graz, Austria

Note: [*] Inst. of Physic. Chern. University Graz, Austria

Note: [] Accepted by: Editor A.M. Ehrly

Abstract: In a series 43 patients suffering from cerebral or peripheral diseases were investigated over a period of 3 days after a single hypervolemic hemodilution with 500ml low molecular weight dextran (Rheomacrodex®) applied within 3 hours. Changes in hematocrit, visco-elasticity of whole blood and plasma viscosity were studied. 18 to 36 hours after onset of infusion a significant increase in plasma viscosity (p⩽0.001) and elasticity (p⩽0.01) could be observed. Furthermore, there was a tendency towards higher hematocrit and whole blood viscosity levels. However, after 60 hours a second lower numerical peak for hematocrit and viscosity of whole blood could be seen, which was yet above starting values.

Keywords: Hemodilution, dextran, viscoelasticity, plasma viscosity, hematocrit

DOI: 10.3233/CH-1988-8522

Journal: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 763-771, 1988