The role of red cells subpopulations in the determination of erythrocyte deformability

Issue title: The Fifth European Conference on Clinical Hemorheology. Part I

Article type: Research Article

Authors: Franzini, E.^a | Driss, F.^b | Driss, Fr.^c | Daoud, F.^b | Darcet, Ph.^b | Thao Chan, M.^a

Affiliations: [a] Hemorheology Lab., Hoechst Laboratories, 92800 Puteaux, France | [b] Hôp. Ste Perrine, 75016 Paris, France | [c] CTS, Hôp. Laënnec, 75014 Paris, France

Note: [] Accepted by: Guest Editor J.C. Healy

Abstract: Erythrocyte deformability (E.D.) was investigated by two filtration techniques: the Hanss’hemorheometer and the Cell Transit Time Analyzer (CTA) in elderly subjects and in subjects with liver diseases. Unlike the hemorheometer, the CTA technique is in a position to analyze the deformability of each red cell passing through 5 µm pores of a polycarbonate filter (Oligopore) under a low hydrostatic pressure. Both methods showed that E.D. was lower in the elderly group and in the liver diseases group than in the control group. Another characteristic of the CTA is to detect a few fractions of less deformable red cells.

Keywords: CTA, Erythrocyte Deformability, red cell subpopulations

DOI: 10.3233/CH-1988-83-429

Journal: Clinical Hemorheology and Microcirculation, vol. 8, no. 3-4, pp. 493-499, 1988