Macro and microrheological determinants in chronic renal failure

Issue title: The Fifth European Conference on Clinical Hemorheology. Part I

Article type: Research Article

Authors: Caimi, Gregorio^a | Vaccaro, Francesco^b | Serra, Antonio^a | Picone, Francesco^b | Romano, Adele^a | Sarno, Antonio^a

Affiliations: [a] Istituto di Clinica Medica e Malattie Cardiovascolari, Universitá di Palermo, Via del Vespro 129, 90127, Palermo | [b] Istituto di Patologia Chirurgica R, Universitá di Palermo, Via del Vespro 129, 90127, Palermo

Note: [] Accepted by: Guest Editor M. Duchesne-Gueguen

Abstract: In a group of subjects with chronic renal failure (CRF) not yet in need of dialysis therapy we evaluated macro and microrheological determinants. From the obtained data it is evident that the whole-blood filterability as well as red cell aggregation discriminate normals from subjects with CRF. Same behaviour is present regarding the erythrocyte membrane fluidity. This parameter evaluated using fluorescence technique, distinguishes clearly normals from subjects with CRF. The datum regarding the red cell membrane fluidity suggests that in these patients a membrane structural alteration is present. This alteration seems dependent on the oxidative and lipidic metabolism that is altered in this pathology.

Keywords: Chronic renal failure, red cell membrane fluidity, whole-blood filterability, erythrocyte aggregation

DOI: 10.3233/CH-1988-83-421

Journal: Clinical Hemorheology and Microcirculation, vol. 8, no. 3-4, pp. 433-437, 1988