Affiliations: [a] Centre régional de transfusion sanguine de Rennes, France | [b] Service d’hémodialyse, C.H.U. Ponchaillou, Rennes, France | [c] A.U.B. C.H.U. Ponchaillou, Rennes, France
Note: [] Accepted by: Editor H. Schmid-Schönbein
Abstract: Erythrocyte abnormalities are likely to play a role among the contributory factors to anaemia in patients with chronic renal failure, We therefore thought it of interest to study such patients’ hemorheological parameters and assess the influence of dialysis on those parameters, The present study was carried out on 71 patients with chronic renal failure (CRF): 12 non-dialysed patients (NO), 36 patients undergoing regular hemodialysis (HD), 23 patients undergoing continuous ambulatory peritoneal dialysis (CAPD), and 40 controls, Blood samples were collected from HO patients before and after the dialysis session, and from CAPD patients at three different times: 1-Empty peritoneal cavity; 2-Two hours after infusion of an isotonic solution; 3-Two hours after infusion of a hypertonic solution, The parameters under study were erythrocyte filterability (Erythrometer, Hemorheometer), blood and plasma viscosities (LS 30), erythrocyte ATP, RBC morphology by scanning electron Microscopy, as well as hematological and biological parameters, The results revealed hemorheological disturbances in all patients as to erythrocyte filterability and plasma viscosity, whole blood viscosity retaining undisturbed because of the decrease in hematocrit, It appears that treatment by dialysis improves the patients’ hemorheological parameters, especially in CAPD patients, There is no significant difference in hemorheological results of dialysed patients between before and after the hemodialysis session, nor between the various CAPD times, Dialysis treatment does not seem to amplify the hemorheological disturbances reported.
