Influence of erythrocyte anisocytosis on filterability through 3 µm diameter pores

Article type: Research Article

Authors: Bareford, D.^{a; b} | Stone, P.C.W.^{a; b} | Girling, A.J.^{a; b} | Gyde, O.H.B.^{a; b} | Stuart, J.^{a; b; *}

Affiliations: [a] Department of Haematology and Department of Statistics, University of Birmingham, Birmingham B15 2TJ, U.K. | [b] Department of Haematology, East Birmingham Hospital, Birmingham B9 5ST, U.K.

Correspondence: [*] Correspondence to: Professor J. Stuart, Department of Haematology, Medical School, Birmingham B15 2TJ, UK.

Note: [] Accepted by: Editor M.R. Boisseau

Abstract: Erythrocyte filterability through pores of nominal 3 µm diameter was studied in 37 patients with microcytosis secondary to iron depletion. The index of filtration (IF) was dependent on both the mean cell volume (MCV) and the degree of anisocytosis (red cell volume distribution width; RDW) of the erythrocyte suspension. A significant correlation (r = 0.78, p < 0.001) was found between IF and MCV + 1.62 RDW. When microcytosis is associated with anisocytosis, subpopulations of relatively large microcytes may have a disproportionate effect on filterability through 3µm diameter pores.

Keywords: Rheology, Erythrocyte deformability, Erythrocyte indices

DOI: 10.3233/CH-1988-8207

Journal: Clinical Hemorheology and Microcirculation, vol. 8, no. 2, pp. 189-194, 1988