Affiliations: Department of Physiology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand | Department of Immunology, Chulabhorn Research Institute, Bangkok, Thailand | Queen Sirikit Blood Center, Ramathibodi Hospital, Bangkok, Thailand | Department of Pediatrics, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
Note: [] Corresponding author: Narisa Futrakul, Dept. of Physiology, King Chulalongkorn Memorial Hospital, Rama IV Road, Bangkok 10330, Thailand. E‐mail: fmednft@md2.md.chula.ac.th.
Abstract: A persistent proteinuria is commonly observed in nephrotic patient with focal segmental glomerulosclerosis (FSGS) under treatment with prednisolone ± cyclophosphamide or with vasodilators (ACEI + AII receptor antagonist, calcium channel blocker and antiplatelet agent). Fourteen such patients with persistent proteinuria were subject to be treated with Ganoderma lucidum. Initial study revealed an enhanced endothelial cell cytotoxicity induced by patient's serum, and an altered immunocirculatory balance with predominant proinflammatory cytokine TNF alpha activity in the presence of defective anti‐inflammatory cytokine interleukin‐10. Treatment with Ganoderma lucidum suppressed endothelial cell cytotoxicity, restored immunocirculatory balance and successfully suppressed proteinuria in all of these 14 patients.
