Affiliations: Department of Operative Techniques and Surgical Research, Medical and Health Science Centre, Faculty of Medicine, University of Debrecen, Hungary | National Institute of Traumatology, Budapest, Hungary
Note: [] Corresponding author: Norbert Nemeth, MD, Department of Operative Techniques and Surgical Research, Medical and Health Science Centre, University of Debrecen, Nagyerdei krt. 98, H‐4032 Debrecen, Hungary. Tel./Fax: +36 52 416 915; E‐mail: nemeth@jaguar.dote.hu.
Abstract: We have studied systemic and regional changes in hemorheological parameters after complete acute limb ischemia and reperfusion (I/R) in 24 mongrel dogs. Unilateral cooled and non‐cooled vascular ischemia (3 h)–reperfusion (4 h), and sham‐operations were performed. Blood samples were collected from the excluded region, during reperfusion and for 5 days. Whole blood and plasma viscosity (WBV, PV), relative cell transit time (RCTT) of erythrocytes, fibrinogen level and hematological parameters were determined. In I/R groups WBV of excluded blood was significantly higher compared to the base (p<0.05), and RCTT increased during the reperfusion. On 2nd–3rd days RCTT increased significantly in both I/R groups. In each group PV and fibrinogen showed continuous increase during the postoperative period, prominently in cooled I/R group, and furthermore WBV corrected for hematocrit (40%) was the highest in cooled I/R group. These suggest that surgical acute limb I/R may cause hemorheological changes, which are more serious after cooling. (Grants: OTKA‐T032571, 6003/1/2001/ETT.)
