Viscometric study of blood from insulin-treated diabetics with and without retinopathy correlation with biological parameters

Article type: Research Article

Authors: Bucherer, C.^a | Lacombe, C.^a | Lelièvre, J.C.^a | Grimaldi, A.^b | Bosquet, F.^b

Affiliations: [a] Unité de Biorhéologie, Université Paris, 6 et CNRS UA 343 CHU, Pitié-Salpêtrière, 75013, Paris | [b] Service de Diabétologie, Hôpital Pitié-Salpêtrière, 75013, Paris

Note: [] Accepted by: Editor J.F. Stoltz

Abstract: A viscometric study of blood from insulin-treated diabetics separated into three clini.cal groups (without retinopathy, with minimal retinopathy and with moderate or severe retinopathy) has been carried on. Among the studied viscometric parameters, three of them, relative to red blood cells (RBC) aggregation, have been found to be more modified in patients with retinopathy than in those without. The results involve (i) a more difficult break off of the blood structure, (ii) a more rigid network structure, (iii) a strong trouble of the rouleaux disaggregation process. These modifications are found closely linked to plasmatic disorders. Furthermore, the deformability of diabetic RBC, evaluated by viscometry is found decreased.

Keywords: Insulin-treated diabetics, Blood viscosity, Retinopathy, Glycosylated hemoglobin, Fibrinogen

DOI: 10.3233/CH-1986-6612

Journal: Clinical Hemorheology and Microcirculation, vol. 6, no. 6, pp. 603-615, 1986