The prediction of high shear whole blood viscosity

Article type: Research Article

Authors: Barbenel, J.C.^a | Barnes, D.J.^{a; *} | Lowe, G.D.O.^b

Affiliations: [a] Bioengineering Unit, University of Strathclyde | [b] Department of Medicine, Glasgow Royal Infirmary, Glasgow, UK

Note: [*] Present address: English China Clays PLC, St Austell. UK

Note: [] Accepted by: Editor J.A. Dormandy

Abstract: Whole blood apparent viscosity was measured at a shear rate of 135s−1 and 37°C, using a conicylindrical rotational viscometer. Multiparameter models were produced by multiple regression analysis of the relationship between measured viscosity and packed cell volume (PCV), plasma fibrinogen concentration and plasma viscosity. The best fit models included PCV and plasma viscosity but not fibrinogen concentration. The 95% confidence limits for the prediction of whole blood viscosity was c ± 21% for data having a wide range of PCV, (22%–77%), and was c ± 10% for data with a smaller PCV range (36% to 48.5%).

Keywords: Blood, plasma, viscosity, packed cell volume, fibrinogen, modelling

DOI: 10.3233/CH-1986-6506

Journal: Clinical Hemorheology and Microcirculation, vol. 6, no. 5, pp. 405-412, 1986