Affiliations: [a] Laboratoire de Biophysique, U.E.R. Biomedicales de Bobigny, 93000 Bobigny, France | [b] U.E.R. Biomedicales des Saints-Pères, 75006 Paris, France | [c] Laboratoire de Biochimie et INSERM U.91, Hopital Henri Mondor, 94010 CRETEIL, France | [d] Hematology Department, Laikon Hospital, Athens, Greece
Note: [] Accepted by: Editor G.A. Marcel
Abstract: By using a new, accurate and sensitive filtration method, we report that at atmospheric pO2 and at 25°C the red blood cell rigidity is highly increased in sickle cell syndromes (SS and AS) and in β thalassemia (minor and intermedia). A rigidity index IR, related to red cell deformabillty was 10 times higher for SS RBCs than that for control AA cells. The heterozygotes states of β thalassemia and of sickle cell disease exhibited an increase in the rigidity index of 90% and 330% of the normal value, respectively.
