Macro and microrheological variations observed during plasma exchange in cases of monoclonal disglobulinemia

Issue title: Proceedings of the Third European Conference on Clinical Hemorheology. Part III. Baden-Baden, F.R. Germany, 24–27 August 1983. Symposium IV. Rheological Aspects of Plasma Separation and Plasmapheresis

Guest editors: Alfred L. Copley and Holger Schmid-Schönbein

Article type: Research Article

Authors: Schooneman, F. | Paulus, F. | Gaillard, S. | Streiff, F. | Stoltz, J.F.

Affiliations: Groupe d’Hemorheologie, Centre de Transfusion Sanguine, Brabois, 54500 Vandoeuvre les Nancy, France

Abstract: Massive plasma exchange (more than 3 litres) can be achieved during various hyperviscosity syndromes using cell separators. The authors report on a rheological survey undertaken on 30 patients with Kahler’s disease, 7 cases of Waldenström’s disease, 2 cases of CLL with monoclonal gammapathy, 3 cases of non Ibdgkinian malignant lymphoma and 2 cases of isolated cryoglobulinemia. The rheological parameters studied covered plasma and blood viscosity, red blood cell aggregability (nephelometry and study with a rheoscope). The results revealed a systematic decrease in plasma and blood viscosity following exchange procedures, with a slow recovery after the exchange. A decrease in aggregability is observed when exchange procedures are carried out using diluted albumin (4%). In conclusion, systematic assessment of the rheological parameters can be considered as a good test for following up plasma exchange procedures during diseases accompanied by a hyperviscosity syndrome.

Keywords: Blood and plasma viscosity, Red Blood cell aggregation, Plasma exchange

DOI: 10.3233/CH-1985-5108

Journal: Clinical Hemorheology and Microcirculation, vol. 5, no. 1, pp. 51-59, 1985