Rheological effects during centrifugal plasma production

Issue title: Proceedings of the Third European Conference on Clinical Hemorheology. Part III. Baden-Baden, F.R. Germany, 24–27 August 1983. Symposium IV. Rheological Aspects of Plasma Separation and Plasmapheresis

Guest editors: Alfred L. Copley and Holger Schmid-Schönbein

Article type: Research Article

Authors: Kellogg, Robert M.

Affiliations: IBM Information Products Division, Boulder, Colorado, USA

Abstract: The effect of patient pathology on plasma production performance during plasma exchange was studied operating a continuous flow centrifugal separator (IBM 2997) in a standardized way. The disease categories were TTP, Neuro-Muscular Disorders, Hyper-Viscosity Syndrome and others (which included Hemolytic Amemia and Goodpastures Syndrome). Plasma production performance was considered from two points of view: Plasma production efficiency and residual platelet count in the separated plasma. Analysis of 254 procedures showed plasma separation efficiency is high – greater than 80% – and not strongly affected by patient pathology. Platelet clearance from separated plasma is dependent on patient pathology and was found to range from 60% to 90%.

Keywords: Centrifugation, plasma exchange, plasma separation

DOI: 10.3233/CH-1985-5106

Journal: Clinical Hemorheology and Microcirculation, vol. 5, no. 1, pp. 35-43, 1985