Affiliations: [a] Faculty of Medicine, Ivane Javakhishvili Tbilisi State University. Tbilisi, Georgia
| [b] Laboratory of Rheology and Diagnosti Analytical Services, Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
| [c] Department of Clinical Research, Multidisciplinary Science High School, Tbilisi, Georgia
| [d] Department of Physics, Biophysics, Biomechanics and IT Technologies, Tbilisi State Medical University, Tbilisi, Georgia
| [e] Department of Cardiopulmonary, Bokhua Memorial Cardiovascular Clinic, Tbilisi, Georgia
| [f] Department of Nutrition, Aging Medicine, Environmental and Occupational Health, Tbilisi State Medical University, Tbilisi, Georgia
| [g] Department of Medicine, UNIK-Kutaisi University, Kutaisi, Georgia
Correspondence:
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Corresponding author: Maia Chigogidze, Faculty of Medicine, Ivane Javakhishvili Tbilisi State University. Tbilisi, Georgia. E-mail: rheology.biz@gmail.com.
Abstract: BACKGROUND:In coronary artery disease (CAD), an alternative way of improvement of blood circulation in the ischemic area of the myocardium is coronary collateral circulation. Our study aimed to investigate the rheological parameters of blood and nitric oxide (NO) content in patients with various degrees of collateral development and the likelihood of the influence of blood fluidity on collateral angiogenesis. METHODS:We studied patients with stable CAD who underwent elective coronary angiography and a control group with the same mean age. We investigated patients with different degrees of developing collaterals and those without them. In studied patients, the blood plasma viscosity, aggregability, and deformability of erythrocytes, as the main indicators of blood rheology. We recorded content of stable metabolic end products of nitric oxide (NOx). RESULTS:Results of the studies showed that in the blood of studied patients with CAD erythrocyte aggregation was increased and NO content decreased compared to the control level; NO content was as lower, as less was the number of developed collaterals was recorded. CONCLUSION:In this work, the role of the aggregation ability of erythrocytes and the endothelial origin of NO in the direct and feedback regulatory mechanism of angiogenesis in patients with CAD are discussed.
