Affiliations: Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Regensburg and Caritas Hospital St. Josef Regensburg, Regensburg, Germany
Correspondence:
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Corresponding author: Priv.-Doz. Dr. med. univ. Alexandra M. Anker, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany. Tel.: +49 941 782 3110; E-mail: alexandra.anker@ukr.de.
Note: [1] This article was presented at the 40th Conference of the German Society for Clinical Microcirculation and Hemorheology (DGKMH), Senftenberg, Germany, 20–21 May 2022.
Note: [2] Authors designated for co-first-authorship.
Abstract: BACKGROUND:Recent studies have demonstrated that local application of corticosteroids reduces wound exudation following abdominoplasty and other reconstructive surgical procedures. On the other hand, corticosteroids might provoke wound healing disturbances due to their immunosuppressive effects. OBJECTIVE:The main objective of this study was to gain further information about the impact of the corticosteroid triamcinolone on cell migration in abdominoplasty patients. METHODS:An in-vitro scratch assay wound healing model was applied to observe cell migration of fibroblasts cultured with nutrient medium containing human seroma aspirate±triamcinolone. RESULTS:There were no significant differences regarding cell migration when fibroblasts were incubated with triamcinolone + seroma containing culture medium compared to seroma containing culture medium without triamcinolone. CONCLUSIONS:The performed in-vitro study suggests that triamcinolone does not decelerate fibroblast cell migration which is considered as a surrogate of wound healing.
