Comprehensive study of the rheological status and intensity of oxidative stress during the progression of type 2 diabetes mellitus to prevent its complications

Article type: Research Article

Authors: Chkhitauri, Lela^{a; *} | Sanikidze, Tamar^{b; c} | Giorgadze, Elene^a | Asatiani, Ketevan^a | Kipiani, Nana^b | Momtselidze, Nana^{c; d; e} | Mantskava, Maka^{b; c; d; f}

Affiliations: [a] Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia | [b] Tbilisi State Medical University, Tbilisi, Georgia | [c] Ivane Beritashvili Experimental Center of Biomedicine, Tbilisi, Georgia | [d] Multidisciplinary Science High School, Tbilisi, Georgia | [e] UNIK-Kutaisi University, Kutaisi, Georgia | [f] European University, Tbilisi, Georgia

Correspondence: [*] Corresponding author: Lela Chkhitauri, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia. E-mail: rheology.biz@gmail.com.

Abstract: BACKGROUND:Prevention of Type 2 diabetes mellitus (T2DM) requires a modifying effect on the pathological processes inducing the β-cell dysfunction. OBJECTIVES:the comprehensive study of the violation of rheological parameters in patients with different stages of diabetes and identification of possible links between these alterations with the intensity of the oxidative stress in the patient’s body. METHODS:60 patients with IR, prediabetes, T2DM and healthy volunteers were included. Full range of the rheological parameters of the patients’ blood - the indicators of erythrocytes aggregation index (EAI), the relative deformability of the erythrocytes membranes (ERDI), blood plasma viscosity (BPV), and oxidative stress intensity (OSI) were examined. RESULTS:In patients with insulin resistance (IR), prediabetes, and T2DM the ERDI was statistically significantly lower and BPV - higher compared to control; a significant increase in EAI was detected in the patient group with prediabetes and T2DM compared to the control. CONCLUSION:The level of rheological disorders in patients increases with the increase of the level of carbohydrate metabolism disorders and intensity of oxidative stress and reaches a maximum during manifested diabetes. Diagnosis of hemorheological disorders and OSI in T2DM can serve as an early marker of target organ damage possibility.

Keywords: Insulin resistance, prediabetes, Type 2 diabetes mellitus (T2DM), rheological parameters, oxidative stress

DOI: 10.3233/CH-221512

Journal: Clinical Hemorheology and Microcirculation, vol. 83, no. 1, pp. 69-79, 2023