Acceleration time to Ejection time ratio in fetal pulmonary artery system can predict neonatal respiratory disorders in gestational diabetic mellitus women

Article type: Research Article

Authors: Wang, Shuya^a | Wang, Yueheng^{b; *} | Gao, Man^c | Tan, Yongpan^c

Affiliations: [a] Department of Cardiac Ultrasound, Hebei Medical University, Shijiazhuang, China | [b] Department of Cardiac Ultrasound, Second Hospital of Hebei Medical University, Shijiazhuang, China | [c] Department of Ultrasound, Shijiazhuang Maternity Hospital, Shijiazhuang, China

Correspondence: [*] Corresponding author: Yueheng Wang, Department of Cardiac Ultrasound, Second Hospital of Hebei Medical University. No. 215, Heping West Road, Shijiazhuang 050000, Hebei, China. Tel.: +8618032937500; E-mail: yuehengwang116@sina.com.

Abstract: BACKGROUND:Few researches studied fetal pulmonary pulse wave doppler and the clinical end point disorders in gestational diabetic mellitus (GDM) cohort. OBJECTIVE:To investigate fetal pulmonary artery acceleration time to ejection time ratio (PATET) in the prediction of neonatal respiratory disorders (NRD). METHODS:238 pregnant women diagnosed with GDM who attended our hospital between February 2018 and March 2020 were retrospectively included. Fetal pulmonary artery Doppler wave measurements were recorded, including main, left and right pulmonary artery blood flow, and left and right peripheral pulmonary artery blood flow. Acceleration time (At)/ejection time (Et) were calculated. RESULTS:183 GDM pregnant women and neonates were divided into NRD(+)(n = 42) and NRD(–) group (n = 141). 16 cases were neonatal pneumonia (NP) within 28 days after birth in NRD(+) group. The area under curve (AUC) of left peripheral pulmonary artery acceleration time to ejection time (LPPATET) was 0.967 (95% CI: 0.927∼1.000, P < 0.001) and the AUC of right peripheral pulmonary artery acceleration time to ejection time (RPPATET) was 0.967 (95% CI: 0.927∼1.000, P < 0.001), indicating that LPPATET and RPPATET are both predictors for NRD. The results of interobserver variabilty and intraobserver variability showed a good consistency. CONCLUSIONS:The At/Et of fetal peripheral pulmonary artery (PPA) in GDM women may be predictors for NRD, and the indicator can provide assistance in clinical management of diabetes pregnant patients.

Keywords: Peripheral pulmonary artery blood flow, acceleration time to ejection time, fetal pulmonary artery doppler, gestational diabetic mellitus, neonatal respiratory disorders

DOI: 10.3233/CH-211265

Journal: Clinical Hemorheology and Microcirculation, vol. 80, no. 4, pp. 497-507, 2022