Multiblock copolymers type PDC – A family of multifunctional biomaterials for regenerative medicine¹

Article type: Research Article

Authors: Ullah, Imram^a | Wang, Weiwei^a | Ma, Nan^{a; c; *} | Lendlein, Andreas^{a; b; c; *}

Affiliations: [a] Institute of Active Polymers and Berlin Brandenburg Centre for Regenerative Therapies (BCRT), Helmholtz-Zentrum Hereon, Teltow, Germany | [b] Institute of Chemistry, University of Potsdam, Potsdam, Germany | [c] Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany

Correspondence: [*] Corresponding author: Prof. Dr. Nan Ma and Prof. Dr. Andreas Lendlein, Helmholtz-Zentrum Hereon, 14513 Teltow, Kantstraße 55, Germany. E-mails: nan.ma@hereon.de (Nan Ma);andreas.lendlein@hereon.de(Andreas Lendlein).

Note: [1] Dedicated to Dr. Karl Kratz.

Abstract: Multiblock copolymers type PDC are polyetheresterurethanes composed of poly(ɛ-caprolactone) and poly(p-dioxanone) segments. They were designed as degradadable shape-memory polymers for medical devices, which can be implanted minimally-invasively. While providing structural support in the initial phase after implantation, they are capable to modulate soft tissue regeneration while degradation. In this perspective, we elucidate cell-material interactions, compatibility both in-vitro and in-vivo and biofunctionality of PDC, which represents a promising candidate biomaterial family especially for cardiovascular applications.

Keywords: Multiblock copolymers PDC, biofunctionality, soft tissue regeneration

DOI: 10.3233/CH-211264

Journal: Clinical Hemorheology and Microcirculation, vol. 80, no. 3, pp. 327-341, 2022