Characterization of cervical lymph nodes using DCE-MRI: Differentiation between metastases from SCC of head and neck and benign lymph nodes

Article type: Research Article

Authors: Yan, Shuo^{a; b; 1} | Wang, Zhiye^{c; 1} | Li, Li^d | Guo, Yu^b | Ji, Xiaodong^b | Ni, Hongyan^b | Shen, Wen^{b; *} | Xia, Shuang^{b; *}

Affiliations: [a] Department of Radiology, Beijing Ditan Hospital, Capital Medical University, China | [b] Department of Radiology, Tianjin First Central Hospital, China | [c] Department of Radiology, Yuhuang Ding Hospital, China | [d] Department of Otolaryngology-Head and Neck Surgery, Tianjin First Central Hospital, China

Correspondence: [*] Corresponding author: Shuang Xia and Wen Shen, 24 Fukang Road, Nankai District, Tianjin 300192, China. Tel.: +86 15802259560; Fax: +86 02223626583; E-mail: xiashuang77@163.com (S. Xia), Tel.: +86 15900209418; Fax: +86 02223626583; E-mail: shenwen66happy@163.com (W. Shen).

Note: [1] Shuo Yan and Zhiye Wang participated to an equal extent in planning, analyzing, evaluation, and writing the paper.

Abstract: PURPOSES: To compare the characteristics of DCE-MRI between metastatic and benign lymph nodes (LNs). To explore the effect of sizes of LNs on the value of Ktrans, Ve and iAUC. MATERIALS AND METHODS: Metastatic and benign LNs were retrospectively analyzed. Chi-square test and two sample t-test were applied to TICs and parameters. One factor covariance analysis was used to explore the effect of diameters on the value of Ktrans, Ve and iAUC. RESULTS: The value of Ktrans, Ve and iAUC of metastatic LNs were statistically higher (all p < 0.001) than those of benign LNs. The short-axis diameters had no influence on parameters. CONCLUSIONS: DCE-MRI is useful to differentiate the metastatic LNs from benign LNs. Sizes of LNs has no effect on parameters.

Keywords: Dynamic contrast-enhanced magnetic resonance imaging, lymph node, head and neck squamous cell carcinoma

DOI: 10.3233/CH-162065

Journal: Clinical Hemorheology and Microcirculation, vol. 64, no. 2, pp. 213-222, 2016