Lipid peroxidation and nitric oxide metabolites in a group of subjects with obstructive sleep apnea syndrome

Article type: Research Article

Authors: Caimi, Gregorio^* | Presti, Rosalia Lo | Montana, Maria | Urso, Caterina | Canino, Baldassare | Hopps, Eugenia

Affiliations: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Italy

Correspondence: [*] Corresponding author: Gregorio Caimi, Dipartimento Biomedico di Medicina Interna e Specialistica, Università degli Studi di Palermo, Via del vespro 129, 90100 Palermo, Italy. Tel.: +39 091 6554406; Fax: +39 091 6554535; E-mail: gregorio.caimi@unipa.it.

Abstract: It is known that in OSAS the plasma lipid peroxidation has an opposite behavior in comparison with nitric oxide metabolites. In the re-examination of our survey of OSAS subjects we calculated the ratio between thiobarbituric acid reactive substances (TBARS) and nitric oxide metabolites (NOx) in relation to OSAS severity. The study has regarded 48 OSAS subjects subdivided in two subgroups according to the apnea/hypopnea index – AHI- (Low = 21 subjects with AHI <30 and High = 27 subjects with AHI >30). From the obtained data it is evident that the TBARS/NOx ratio is significantly higher in the H subgroup compared to L subgroup as well as this ratio is reduced in L subgroup in comparison with the whole group of OSAS subjects. In the entire group of OSAS subjects the TBARS/NOx ratio results positively correlated with AHI and ODI and inversely correlated with mSO2.

Keywords: Lipid peroxidation, nitric oxide metabolites, obstructive sleep apnea syndrome

DOI: 10.3233/CH-152016

Journal: Clinical Hemorheology and Microcirculation, vol. 63, no. 2, pp. 163-168, 2016