Adjuvant drug-assisted bone healing: Part III – Further strategies for local and systemic modulation

Issue title: Bone Healing

Guest editors: J. Pietzsch and F. Jung

Article type: Research Article

Authors: Rothe, Rebecca^a | Schulze, Sabine^{b; c} | Neuber, Christin^a | Hauser, Sandra^a | Rammelt, Stefan^{b; c; d; 1; *} | Pietzsch, Jens^{a; e; 1; *}

Affiliations: [a] Department of Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany | [b] University Center of Orthopaedics and Traumatology (OUC), University Hospital Carl Gustav Carus, Dresden, Germany | [c] Center for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany | [d] Center for Regenerative Therapies Dresden (CRTD), Tatzberg 4, Dresden | [e] Technische Universität Dresden, School of Science, Faculty of Chemistry and Food Chemistry, Dresden, Germany

Correspondence: [*] Corresponding authors: Prof. Dr. Stefan Rammelt, University Center for Orthopaedics and Traumatology, University Hospital Carl Gustav Carus, Fetscherstrasse 74, 01307; Dresden, Germany. Tel.: +49 351 4583211; Fax: +49 351 4584307; E-mail: stefan.rammelt@uniklinikum-dresden.de and Jens Pietzsch, Department of Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328, Dresden, Germany. Tel.: +49 351 2602622; Fax: +49 351 26012622; E-mail: j.pietzsch@hzdr.de.

Note: [1] Stefan Rammelt and Jens Pietzsch share senior authorship.

Abstract: In this third in a series of reviews on adjuvant drug-assisted bone healing, further approaches aiming at influencing the healing process are discussed. Local and systemic modulation of bone metabolism is pursued with use of a number of drugs with completely different indications, which are characterized by a pleiotropic spectrum of action. These include drugs used to treat lipid disorders (HMG-CoA reductase inhibitors), hypertension (ACE inhibitors), osteoporosis (bisphosphonates), cancer (proteasome inhibitors) and others. Potential applications to enhance bone healing are discussed.

Keywords: Bisphosphonates, bone metabolism, critical-size bone defects, small molecules, statins, strontium, Wnt signaling

DOI: 10.3233/CH-199104

Journal: Clinical Hemorheology and Microcirculation, vol. 73, no. 3, pp. 439-488, 2019