Affiliations: [a] Department of Internal Medicine, Division of Angiology, University Hospital, Basel, Switzerland | [b] Department of Radiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA | [c] Department of Radiology, Kantonsspital Laufen, Laufen, Switzerland | [d] Department of Rheumatology, University Hospital Basel, Basel, Switzerland
Correspondence:
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Corresponding author: Daniel Staub, MD, Department of Internal Medicine, Division of Angiology, University Hospital Basel, Petersgraben 4, CH- 4031 Basel, Switzerland. Tel.: +41 61 265 51 57; Fax: +41 61 265 53 56; E-mail: daniel.staub@usb.ch.
Abstract: PURPOSE:The purpose was to evaluate skeletal muscle microcirculation by means of quantitative dynamic contrast-enhanced ultrasound (DCEUS) in patients with systemic sclerosis (SSc). METHODS:DCEUS imaging of the gastrocnemius muscle was performed with phospholipid-stabilized microbubbles filled with sulfur hexafluoride in 12 patients with SSc and 12 healthy volunteers. The fitted time intensity curves (TIC) during the first 3 minutes after administration of the contrast agent bolus were analysed. Time course parameters of the TIC were compared between patients and healthy volunteers. RESULTS:Peak enhancement, wash-in area under the curve and was-out area under the curve was decreased in the patient group versus healthy volunteers (168 versus 248 AU p = 0.291; 2193 versus 3314 p = 0.198; 4948 AU x sec versus 8948 AU x sec p = 0.037). In the SSc patients the mean transit time and wash-in perfusion index were numerically, but not statistically lower than in the healthy volunteers, but rise and fall time were similar. CONCLUSION:On the microvascular level in SSc patients versus their healthy counterpart key parameters related to blood volume were decreased and perfusion parameters showed a slight diminishment in the patient population. These results suggest a component of impaired skeletal muscle microcirculation in SSc patients.
