Affiliations: [a] INSERM U1046, Physiopathologie & Médecine Expérimentale du Cœur et des Muscles, Equipe d’Explorations Métaboliques (CERAMM), Université Montpellier 1, Université Montpellier 2, Département de Physiologie Clinique, Hôpital Lapeyronie CHU Montpellier, France | [b] Institut des Biomolécules Max Mousseron (IBMM) UMR CNRS 5247, Université Montpellier 1, Université Montpellier 2, Ecole Nationale Supérieure de Chimie de Montpellier, France | [c] Laboratoire de Biophysique & Bio-Analyses, Faculté de Pharmacie, Université Montpellier 1, France
Correspondence:
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Corresponding author: Jean-Frédéric Brun, INSERM U1046, Physiopathologie & Médecine Exprimentale du Cœur et des Muscles, Equipe d’Explorations Métaboliques (CERAMM), Université Montpellier 1, Université Montpellier 2, Département de Physiologie Clinique, Hôpital Lapeyronie CHU Montpellier, France. Tel.: +33 467338284; Fax: +33 467338986; E-mail: j-brun@chu-montpellier.fr.
Abstract: We previously reported that low intensity endurance training in sedentary patients suffering from the metabolic syndrome improves blood rheology, mostly due to a decrease in plasma viscosity correlated with an increase in cardiorespiratory fitness. We investigated whether these findings can be extended to type-2 diabetics. 22 diabetics (11 women and 10 men, age: 52.00 ± 2.9 yr, BMI: 32.47 ± 1.17 kg/m2) were tested before and after 2 months. Eight of them were trained (2 to 3×45 min/wk) at the power intensity where lipid oxidation reaches a maximum (LIPOX max) and thirteen served as controls. Over this period the only significant hemorheological effect of training was a decrease in RBC aggregation “M” (−1.25 ± 0.357 p = 0.01) in the trained group. Subjects who lost weight exhibited a decrease in plasma viscosity (from 1.46 ± 0.013 to 1.38 ± 0.02 p < 0.01). Changes in waist circumference are associated with changes in hematocrit (r =−0.952 p = 0.01); plasma viscosity (r =−0.91; p = 0.03); RBC aggregation (“M” r = 0.940; p = 0.02). Subjects can also be divided into those who improved their aerobic capacity VO2max and those whose VO2max decreased or remained unchanged. An increase in VO2max is associated with a decrease in whole blood viscosity (r =−0.79 p = 0.06) explained by an improvement in RBC rigidity “Tk” (r =−0.963 p = 0.002). This study suggests that in Type 2 diabetic patients: (a) viscosity factors might be less responsive to training than in non diabetic individuals; (b) visceral fat loss is the main determinant of changes in hematocrit, plasma viscosity and RBC aggregation; (c) improvements in aerobic capacity improves blood viscosity via an increase in RBC deformability.
