Issue title: Selected Presentations held at the 33th Annual Conference of the German Society for Clinical Microcirculation and Hemorheology, Villingen-Schwenningen, Germany, 14-15 November, 2014
Article type: Research Article
Authors: Klotz, Laura V. | Ingrisch, Michael | Eichhorn, Martin E. | Niemoeller, Olivier | Siedek, Vanessa | Gürkov, Robert | Clevert, Dirk-Andre
Affiliations: Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, University of Munich, Munich, Germany | Institut of Clinical Radiology, University of Munich, Munich, Germany | Department of Thoracic Surgery, University of Heidelberg, Munich, Germany | Department of Radiation Oncology, University of Munich, Munich, Germany | Department of Otorhinolaryngology, University of Munich, Munich, Germany
Note: [] Corresponding author: Laura V. Klotz, MD, Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany. Tel.: +49 89 85791 0; Fax: +49 89 85791 4206; E-mail: laura.klotz@med.uni-muenchen.de
Abstract: PURPOSE: Contrast enhanced ultrasound (CE-US) is a promising imaging modality for non-invasive analysis of functional vascularisation. Lesions of the parotid gland are associated with a vascularisation that differs from normal gland tissue. The aim of this clinical study was to further analyse the perfusion in parotid gland lesions with CE-US. The new quantification software VueBox (Bracco, Italy) was used to assess the perfusion, based on DICOM datasets of CE-US examination. MATERIALS AND METHODS: CE-US measurements were performed by intravenous application of a contrast agent (SonoVue, Bracco, Italy) before surgical tumor resection. From the analysis of a time sequence of 2D DICOM contrast images, area under time intensity curve (AUC), peak enhancement (PE), wash-in-rate (WiR) and wash-in-perfusion-index (WiPI) were calculated using VueBox. These were correlated with the histological analyses of the tumor tissue. RESULTS: Significant difference of area below intensity time curve (AUC), peak enhancement (PE), wash-in-rate (WiR) and wash-in perfusion index (WiPI) were observed in the malign lesions compared to benign tumors (p < 0,05) and in pleomorphic adenoma compared to cystadenolymphoma (p < 0,05). CONCLUSION: CE-US seems to be a quantitative and independent method for discriminating between malign and benign parotid gland tumors.
Keywords: Parotid gland, contrast enhanced ultrasound, tumor microcirculation, salivary gland, tumor, perfusion, imaging
DOI: 10.3233/CH-141895
Journal: Clinical Hemorheology and Microcirculation, vol. 58, no. 1, pp. 261-269, 2014
