Affiliations: [a] Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Università degli Studi di Palermo, Palermo, Italy | [b] Department of Psychology, Educational Science and Human Movement, Università degli Studi di Palermo, Palermo, Italy
Correspondence:
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Corresponding author: Prof. Gregorio Caimi, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Università degli Studi di Palermo, Via del Vespro 129, 90127, Palermo, Italy. Tel.: +39 09173294406; E-mail: gregorio.caimi@unipa.it.
Abstract: Although the inherited quantitative and qualitative disorders of fibrinogen are rare, in the course of time patients may develop complications including episodes of arterial and venous thrombosis. It can be useful to complete the laboratory assessment of these clinical conditions with the evaluation of the haemorheological profile. The data obtained from this study showed that congenital afibrinogenemia was characterized by a primary plasma hypoviscosity, whereas congenital dysfibrinogenemia by a primary plasma hyperviscosity. Both these haemorheological alterations may concur, with different mechanisms, to the pathogenesis of thrombotic vascular complications.
