Affiliations: [a] Research Center, Hospital Universitario y Politécnico La Fe, Valencia, Spain | [b] Dermatology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain | [c] Hemostasis Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain | [d] Internal Medicine Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain | [e] Radiology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain
Correspondence:
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Corresponding author: Vicenta Martínez-Sales, PhD, Research Center, Hospital Universitario y Politécnico La Fe, Avda. Campanar 21, 46009 Valencia, Spain. Tel.: +34 963862700/Ext: 50551; Fax: +34 961973018; martinez_vicsal@gva.es
Abstract:
INTRODUCTION: Psoriasis is a chronic pathology characterized by increased inflammation that can be associated with changes in the vascular endothelium. We quantified the levels of circulating endothelial cells (CECs) and microparticles (MPs) in patients with psoriasis in order to analyze their relationship with endothelial and inflammation markers, subclinical atherosclerosis and microcirculation.
METHODS: We studied 20 patients and 20 controls. Circulating markers of endothelial damage (CEC, MPs and von Willebrand factor, vWF) and inflammation (E-selectin, E-sel; Interleukin-6, IL-6 and C-reactive protein, CRP) were determined. Subclinical atherosclerosis was assessed by carotid ultrasound to obtain intima-media thickness. Microcirculation was evaluated by nailfold capillaroscopy.
RESULTS: CECs, MPs, vWF, CRP and E-sel levels were significantly elevated in patients when compared with controls (p < 0.05). Ninety-four and fifty-three percentage of patients had CEC and MP levels higher than 99th percentile in controls. Forty-seven percent of patients simultaneously showed increased CEC and MP levels. MPs correlate with the inflammatory markers and with the intima-media thickness. CECs correlate with the capillaries loops per mm (p < 0.05).
CONCLUSION: Psoriasis patients show elevated CECs and MPs, as a sign of endothelial dysfunction, which correlates with inflammatory markers as well as subclinical atherosclerosis and some capillaroscopy findings.
