Issue title: Hemostasis
Article type: Research Article
Authors: Wei, Xi | Li, Ying | Zhang, Sheng | Li, Xubin | Wang, Hailing | Yong, Xu | Wang, Xiaoqing | Li, Xing | Gao, Ming
Affiliations: Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China | The Third Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China | Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China | Department of Thyroid and Cervical Tumor, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
Note: [] Xi Wei, Ying Li and Sheng Zhang contributed equally to this work.
Note: [] Xi Wei, Ying Li and Sheng Zhang contributed equally to this work.
Note: [] Xi Wei, Ying Li and Sheng Zhang contributed equally to this work.
Note: [] Corresponding author: Ming Gao, MD., PhD., Department of Thyroid and Cervical Tumor, Tianjin Medical University Cancer Institute and Hospital, Key laboratory of Cancer Prevention and Therapy, Huanhuxi Road, Hexi District, Tianjin 300060, China. Tel.: +86 13820881516; Fax: +86 22 23355901; E-mails: weixi198204@126.com; ddmm74@gmail.com (Y. Li); zs19620112@126.com (S. Zhang).
Abstract: OBJECTIVE: To evaluate the dynamic microvascularization of focal salivary gland lesions by contrast-enhanced ultrasound (CEUS) and Color Doppler sonography. MATERIALS AND METHODS: One hundred and sixty-eight patients with 183 major salivary gland lesions (mean age, 56 years; age range, 12–83 years) underwent gray-scale ultrasonography (US), Color Doppler (CD) and CEUS. The CD and CEUS patterns were classified into three types (scores 0–3). Combined score grades were calculated based on the CD and CEUS pattern scores. The time-intensity curve (TIC) parameters of CEUS were then analyzed. Sensitivity, specificity, negative predictive value and positive predictive value of combined score grades were also calculated. RESULTS: Among all the lesions, there were 161 in parotid gland, 22 in submandibular gland and 157 lesions were benign and 26 were malignant. For score grades (combined CEUS patterns with CD types), scores 1-2 were graded as benign; scores 3-4 were graded as indetermination-suspicious benign or malignant and scores 5-6 were graded as malignant.score 5-6 and score 1-2 indicated 24 (92.3%) and 135 (85.9%) malignant and benign lesions confirmed pathologically, respectively. The sensitivity and negative predicted value of combined score grades for malignant lesions were 92.3% and 98.5%, respectively. In addition, TIC analysis indicates that PI and AUC in malignant lesions were higher than those in benign lesions (p = 0.04 and 0.02, respectively). CONCLUSION: The combined score grade could be a useful method to assess the macro-and micro-vascularization and to differentiated diagnose benign and malignant lesions in major salivary glands.
Keywords: Salivary gland lesions, microvascularity, CEUS, Color Doppler, combined score grade
DOI: 10.3233/CH-131732
Journal: Clinical Hemorheology and Microcirculation, vol. 54, no. 3, pp. 259-271, 2013
