Effect of Ioxaglate on the cutaneous microcirculation in patients with coronary artery disease: Randomized, double blind, placebo-controlled study
Issue title: Selected Presentations held at the 35th Conference of the German Society for Clinical Microcirculation and Hemorheology, Mainz, Germany, 4-5 November, 2016
Affiliations: [a] Krankenhaus Dresden-Friedrichstadt, II. Medizinische Klinik, Dresden, Germany
| [b]
Institute for Heart and Circulation Research, Eißendorfer Pferdeweg, Hamburg-Harburg, Germany
| [c] Praxisklinik Herz und Gefäße, Dresden, and Brandenburgische Technische Universität (BTU), Cottbus-Senftenberg, Germany
| [d] Department of Biomaterials, Central Institute for Biomedical Engineering, University of Ulm, Ulm, Germany
| [e]
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany
Correspondence:
[*]
Corresponding author: F. Jung, Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany. Tel.: +03328 352 269; Fax: +03328 352 452; E-mail: friedrich.jung@hzg.de.
Abstract: Radiographic contrast media (RCM) can initiate microcirculatory disorders. This study was performed to investigate effects of Ioxaglate on the cutaneous microcirculation. The investigation was carried out as prospective randomized double-blind comparison in parallel-group design on two groups of n = 10 patients each who had to undergo a diagnostic coronary angiography. The confirmatory parameter of the study was mean erythrocyte capillary velocity [vRBC in mm/sec]. VRBC in the ipsilateral nail-fold capillaries was recorded continuously for 3 min before and 6 min after injection of RCM or isotonic saline solution in the A. axillaris respectively, and was evaluated off-line. VRBC in nailfold capillaries was found to be decreased by Ioxaglate by 34% 150 seconds after injection, while isotonic NaCl solution immediately induced a slight increase of 14%.
