Affiliations: Service Central de Physiologie Clinique, Centre d’Exploration et de Réadaptation des Anomalies du Métabolisme Musculaire (CERAMM) | Service d’Endocrinologie, Hôpital Lapeyronie, 34295 Montpellier‐cédex 5, France
Note: [] Corresponding author: Dr J.F. Brun, MD, PhD, Service Central de Physiologie Clinique, Centre d’Exploration et de Réadaptation des Anomalies du Métabolisme Musculaire (CERAMM), CHU Lapeyronie, 34295 Montpellier‐cédex 5, France. Tel.: +33 04 67 33 82 84; Fax: +33 04 67 33 59 23; Telex: CHR MONTP 480 766 F; E‐mail: drjfbrun@aol.com.
Abstract: Growth hormone deficiency (GHD) in adults results in alterations of body composition and metabolism associated with a lowered insulin sensitivity and an increased cardiovascular risk. Since hemorheologic disturbances (putative factors of vascular risk) are found in the insulin‐resistance syndrome, we investigated blood rheology in 9 adults GHDs (5 men, 4 women; age 37.9\pm 4.7 years; body mass index 30.23\pm 3.2 kg/m^{2}) compared with 23 lean controls and 37 controls matched for sex, age and body mass index. While this sample of GHDs exhibits the typical metabolic picture of this syndrome (upper body overweight with a waist‐to‐hip ratio at 0.91\pm 0.07; low HDL cholesterol at 1.07\pm 0.09 mmol.l^{-1}; low insulin sensitivity with the minimal model technique at 3.3\pm 1.29 min^{-1}/(\muU/ml).10^{-4}) they have similar values of blood viscosity at either native or corrected hematocrit, similar hematocrit, similar red cell rigidity viscometric index, similar red cell aggregation parameters than overweight matched controls. There is only a nonsignificant tendency for plasma viscosity to be higher in GHDs: this tendency becomes significant when women are considered alone (GHDs: 1.44\pm 0.04 mPa.s; controls: 1.31\pm 0.04 mPa.s, p<0.05) while it is no longer found in men. This study suggests that GHDs exhibit the classical hemorheological disturbances of non‐GHD individuals with the same degree of obesity. There is no evidence for a further impairment of blood rheology associated with the specific metabolic and endocrine pattern of GHDs that may be involved in their increased vascular risk.
