Hypervolumetric hemodilution with HES 200/0.5 10% in patients with myocardial microangiopathy, normal left-ventricular function and anglo graphically free coronary system
Affiliations: Institut für Transfusionsmedizin und Immunhämatologie, Universitätsklinikum Charite, Medizinische Fakultat der Humboldt Universität zu Berlin, D-l0098 Berlin, Germany | Abteilung für klinische Hämostaseologie und Transfusionsmedizin, Universitätskliniken des Saarlandes, D-66421 Homburg/Saar, Germany | Med. Klinik und Poliklinik, Innere Medizin III, Universitätskliniken des Saarlandes, D-66421 Homburg/Saar, Germany
Abstract: The clinical benefit of hypervolumtric hemodilution combined with venesection applying 8 infusion of HES 200/0.5 10% (C2/C6 substitution ratio: 4.6) versus 8 Infusions of 250 ml Ringers' solution (p<0.05) was observed in this double blind placebo controlled crossover study on 20 patients (12 men, 8 women) of an average age of 58 with complaints of pectangina but free coronary system and/or symptoms of dyspnea and ischemia during stress ECGs or stress induced hypertension even at low stress levels. Only 2 patients presented mild side effects (hypertension, pectangina) without residual complaints. HES improved the microcirculation of the skin. HES increased blood fluidity relevantly with particular influence on the plasma viscosity, the erythrocyte aggregation and hematocrit. Both infusion solutions decreased the systolic and diastolic blood pressure. The patients with pectangina profited clinically the most so that this form of treatment should be limited to this patient group.
Keywords: Hypervolumetric hemodilution, myocardial microangiopathy, normal left-ventricular function and angiographicaUy free coronary system, clinical benefit only for patients with pectangina
