Impaired function of fibrinogen: Consequences on red cell aggregation in diabetes mellitus

Article type: Research Article

Authors: Khodabandehlou, T. | Le Dévéhat, C.^; | Razavian, M.

Affiliations: Unité de Recherches d'Hémorhéologie Clinique, Pavillon Jules Renault, C.H. 58000 Nevers | Service Diabétologie-Endocrinologie-Maladies Métaboliques, C.H. 58000 Nevers (France) | Depart. of Physiology, Univ. of South California 1333 San Pablo Street, Los Angeles (USA)

Abstract: Two aspects regarding to the functional capacity of fibrinogen for aggregating the red cells were studied in both healthy volunteers and diabetic patients. The first one concerns the activation of the plasminogen that is present in the plasma, thereby involving the susceptibility of the plasma fibrinogen to degradation and ultimatly influencing the red cell aggregation characteristics. The second aspect concerns the quality of fibrinogen and its functional capacity for aggregating red cells. This later is carried-out on isolated and purified fibrinogen from plasma. Experiments made by activating the plasminogen suggest that fibrinogen is less degraded in the plasma of diabetic patients. On the other hand, fibrinogen when isolated from plasma samples of diabetics, is found to be distinct from those obtained from healthy volunteers by its aggregative effects.

Keywords: Fibrinogen, plasminogen activating, red cell aggregation, diabetes

DOI: 10.3233/CH-1996-16310

Journal: Clinical Hemorheology and Microcirculation, vol. 16, no. 3, pp. 303-312, 1996