The influence of intravenous immunoglobulin treatment on the blood rheology in pregnancy

Article type: Research Article

Authors: Heilmann, L.^; | Kriechbaum, A. | v. Tempelhoff, G.-F. | Bode, V. | Wolf, H.

Affiliations: Dept. Obstet. Gynec. City Hospital, 65428 Ruesselsheim | Dept. Clin. Research, Sandoz AG 90426 Nuernberg

Note: [] Correspondence to Prof. L. Heilmann

Abstract: The effect of a commercially available human immunoglobulin G—Sandoglobulin R—on the rheological properties was quantitatively examined in 51 pregnant women with a history of two or more spontaneous abortions. The in vivo effects were assessed during 5 courses of treatment with 150 g, 102 g and 66 g immunoglobulin, respectively. We could not demonstrate a significant effect after IVIG on erythrocyte aggregation, plasma fibrinogen and hematocrit. The dose dependent changes in plasma viscosity that occur after IVIG therapy are compensated by hemodilution.

Keywords: Pregnancy, Immunoglobulin G, plasma viscosity, erythrocyte aggregation

DOI: 10.3233/CH-1995-15308

Journal: Clinical Hemorheology and Microcirculation, vol. 15, no. 3, pp. 359-366, 1995