Affiliations: INSERM U1046, Physiopathologie & Médecine Expérimentale du Cœur et des Muscles, Equipe d'Explorations Métaboliques (CERAMM), Université Montpellier 1, Université Montpellier 2, Département de Physiologie Clinique, Hôpital Lapeyronie CHU Montpellier, France | Laboratoire de Biophysique & Bio-Analyses, Faculté de Pharmacie, Université Montpellier I, France | Laboratoire Performance Santé Altitude, Sciences et Techniques des Activités Physiques et Sportives, Université de Perpignan Via Domitia, France
Note: [] Cor responding author: Dr. Jean-Frédéric Brun, MD, PhD, INSERM U1046, Physiopathologie & Médecine Expérimentale du Cœur et des Muscles, Equipe d'Explorations Métaboliques (CERAMM), Université Montpellier 1, Université Montpellier 2, Département de Physiologie Clinique, Hôpital Lapeyronie CHU Montpellier, France. Tel.: +33 467338284; Fax: +33 467338986; E-mail: j-brun@chu-montpellier.fr
Abstract: In studies using the intravenous glucose tolerance test with minimal model analysis we reported that low insulin sensitivity (SI) is associated with increased erythrocyte aggregability and plasma viscosity, that appeared to be markers of insulin resistance. Recently, development of modelling has made available a new approach of insulin sensitivity from oral glucose tolerance test data (oral minimal model). We aimed at determining in 111 subjects (51 men, 62 women, age 11–77 yr), insulin sensitivity with this approach together with blood viscosity parameters. With this approach the Myrenne indexes of red cell aggregation were negatively correlated to SI (M; r = −0.456; p = 0.0007; M1; r = −0.397; p = 0.004) while plasma viscosity was not. Correlations with fasting insulin levels (Ib) were weaker (M; r = 0.2711; p = 0.05; M1; r = 0.373; p = 0.007). Accordingly, a stepwise regression analysis selects M as the best correlate of SI and M1 as the best correlate of Ib. With this approach plasma viscosity does not exhibit any clear relationship with SI. This study supports the concept that RBC hyperaggregability is the prominent hemorheologic symptom of insulin resistance.
Keywords: Hemorheology, red cell aggregability, insulin resistance, insulin sensitivity, plasma viscosity, minimal model
