Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Ruef, Peter | Zilow, Eugen P. | Linderkamp, Otwin
Affiliations: Division of Neonatology, Department of Pediatrics, University of Heidelberg, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany
Abstract: Volume and deformability of peripheral immature (bands and metamyelocytes) and mature polymorphonuclear neutrophils (PMN) were studied in venous blood of healthy neonates, children and adults. Metamyelocytes were found only in neonatal blood. Membrane cytoplasm tongues of PMN were aspirated into 2.5-μm (diameter) micropipettes over a period of 1 min. Compared with mature PMN, final tongue lengths of band cells were decreased by 44 to 50% and volumes were increased by 14 to 17%. Neonatal metamyelocytes were more rigid and larger than neonatal band cells. Among mature PMN and band cells in the neonates, children and adults cellular volume and deformation behavior were similar. We conclude that immature neutrophils are markedly less deformable than mature PMN and that these cells may contribute to impaired microcirculation in patients with a marked rise of immature neutrophils in peripheral blood.
Keywords: Asphyxia, immature neutrophils, leukocyte deformability, neonates
DOI: 10.3233/CH-1994-14209
Journal: Clinical Hemorheology and Microcirculation, vol. 14, no. 2, pp. 233-236, 1994
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl