Affiliations: Laboratoire de Physiopathologie de la Nutrition, CNRS URA 307, Université Paris 7, 2 place Jussieu 75251 Paris Cedex 05 | Laboratoire de Biorhéologie et d'Hydrodynamique Physicochimique, CNRS URA 343, Université Paris 7, 2 place Jussieu 75251 Paris Cedex 05 | Rhône-Poulenc Rorer-Théraplix, 46-52 rue Albert 75640 Paris Cedex 13 France
Note: [] To whom correspondence should be addressed.
Abstract: We investigated the effect of intravenous 2mM Troxerutine and 10mM α-Tocopherol (Vitamin E) and their combination on erythrocyte aggregation and deformability, blood viscosity and leukocyte adhesivity in rats made mildly diabetic (fasting glycemia: 10mM vs 6mM in controls; HbA1c: 6.5% vs 3% in controls) by a low dose of streptozotocin (35mg/kg) injected via the saphenous vein. In diabetic rats, as compared to controls, erythrocyte aggregation and blood viscosity were dramatically increased (disaggregation shear stress: 5.2 ± 0.4 dynes/cm2 vs 3.7 ± 0.3 dynes/cm2 in controls), whereas erythrocyte deformability and mesenteric blood flow were sharply decreased. Moreover, leukocyte adhesivity was significantly increased. In diabetic rats, the combination of Troxerutine and Tocopherol improved all the above cited parameters. These data show that mild diabetes in rats results in many hemorheological disorders that can be largely corrected by Troxerutine and α-Tocopherol.
Keywords: Blood flow, Red Blood Cell aggregation, White Blood Cell adhesivity, Troxerutine, Diabetes, Vitamin E
