Prostaglandin metabolites and receptor density of platelet glycoprotein IIb-IIIa complex in coronary heart disease

Article type: Research Article

Authors: Mukherjee, Hanjari

Affiliations: Sir H.N.Medical Research Society, Raja Rammohan Roy Road, Bombay 400 004, India

Abstract: The plasma levels of thromboxane B2 (TXB2) and 6-keto prostaglandin F-1α (6-PGF), stable metabolites of thromboxane A2 and prostacyclin respectively, were measured in 23 patients with coronary heart disease (CHD) and 20 healthy subjects who served as controls. The receptor density of glycoprotein (GP) IIb-IIIa complex was determined by an indirect inhibition assay. The mean levels of both TXB2 and 6-PGF were elevated in patients with CHD as compared with controls, the rise being statistically significant in case of 6-PGF (p<0.02), probably resulting from increased biosynthesis of prostacyclin. The receptor density of GP IIb-IIIa complex was enhanced in patients with CHD (p<0.0001). There was a statistically significant positive correlation between TXB2 and receptor density of GP IIb-IIIa in controls (p<0.05), probably indicating their pro-aggregator roles.

Keywords: GP IIb-IIIa complex, thromboxane B[TeX:] $_{2}$, 6-keto prostaglandin F-1α, thrombaxane A[TeX:] $_{2}$, prostacyclin, coronary heart disease

DOI: 10.3233/CH-1993-13607

Journal: Clinical Hemorheology and Microcirculation, vol. 13, no. 6, pp. 759-765, 1993