Affiliations: Hemorheology Department, Beijing Heart Lung & Blood Vessel Medical Research Center, Beijing, 100029, China | Institute of Mecbanlcs, Academy of Sciences of China
Abstract: A three–week investigation was carried out on hemorheological and coagulative indices in rats exposed to carbon monoxide (CO). Results showed that in CO group, clotting times (tG″,tG′) were prolonged with lowered viscous modulus G″ and elastic modulus G′ of thrombus at thirty minute coagulation as well as platelet count (BP). However, hematocrit (Hct) and blood viscosity (BV) in this group were significantly increased. No difference in plasma viscosity (PV) was found between two groups. A correlation was established for the parameters, namely, G′=173.6+100.3PV−5.1Hct−6.6tG′. On the contrary, no alteration in Hct, G″, G′, platelet aggregation activity, clotting time of plasma was found for blood exposed to CO in vitro. But it confirmed there was a strong negative correlation between Hct and G″ (r=−0.938), and G′ (r=−0.974) respectively. These results suggest that: (1) Carbon monoxide does not directly result in changes in thrombotic activity, but it can stimulate the growth of red blood cell by hypoxemia, (2) High Hct is responsible for the reduction of G″ and G′ in CO group.
