Multiple mechanisms of sickle erythrocyte adherence to vascular endothelial cells

Article type: Research Article

Authors: Sugihara, Keiko | Hebbel, Robert P.

Affiliations: Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Abstract: Erythrocytes (RBC) from patients with sickle cell anemia are abnormally adherent to vascular endothelium, and this is believed to participate in development of microvascular occlusion. Various studies of this phenomenon have disagreed regarding mechanism of adhesivity and identity of the most adherent RBC subpopulation. The data can be reconciled by recognizing that several factors may influence adhesivity and lead to variable participation by multiple mechanisms.

Keywords: sickle, erythrocyte, endothelium, vasocclusion, reticulocyte, plasma protein

DOI: 10.3233/CH-1992-12203

Journal: Clinical Hemorheology and Microcirculation, vol. 12, no. 2, pp. 185-189, 1992