Rheological measurements in clinical studies

Article type: Research Article

Authors: Stuart, John

Affiliations: Department Of Haematology, Medical School, University of Birmingham, Birmingham B15 2TT, UK

Abstract: Serial measurement of blood rheology is an important part of the assessment of rheological therapy in clinical trials. A nomogram can be used to calculate the number of patients and matched controls required if a trial is to have the statistical power to show a significant difference in rheological tests. This calculation requires prior knowledge of the precision of the test and of the biological variability of the rheological measurement within the patient group.

Keywords: Rheology, Clinical trials

DOI: 10.3233/CH-1991-11614

Journal: Clinical Hemorheology and Microcirculation, vol. 11, no. 6, pp. 663-665, 1991