Issue title: The Seventh International Congress of Biorheology. Part II, Clinical Hemorheology. Held at Palais des Congrès, Nancy, France, 18–23 June 1989
Guest editors: Alfred L. Copley and Jean-François Stoltz
Affiliations: Department of Medicine, Diakonissenkrankenhaus, Akademisches Lehrkrankenhaus der Univ. Freiburg, 0-7500 Karlsruhe, FRG
Note: [] Accepted by: Editor-in-Chief A. L. Copley
Abstract: Continuously measured oxygen uptake during constant work exercise (15′ SOW) reveals increasing oxygen consumption in individuals with elevated blood viscosity parameters, indicating persistent contribution of anaerobic glycolysis during steady state exercise far below expected “anaerobic threshold”. Improvement of viscosity parameters by prostaglandin E1 infusion (Prostavasin®) 40 µg i.v., naftidrofurylhydrogenoxalat (Dusodril® pi) 400 mg i.v. or hemodilution with 500 ml 6% hydroxyethylamylum MW 40000 (Onkohaes®) in 5 patients results in significant reduction of this oxygen gradient in subsequent exercise test. Integrated V02 during exercise above the mean value at rest or the quotient of V˙O2 during 15 min by V˙O2 during 30 min (including recovery time) are not differing significantly due to high variations inter- and intraindividually. Oxygen gradient during submaximal constant exercise permits direct clinical determination of microcirculatory performance in involved muscle tissue as a function of blood Viscosity.
