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Article type: Research Article
Authors: He, Anbanga; b; 1 | Chen, Zhicongb; c; 1 | Mei, Hongbinga; b; * | Liu, Yuchenb; *
Affiliations: [a] Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen, Guangdong, China | [b] Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University Shenzhen, Guangdong, China | [c] Shantou University Medical College, Shantou, Guangdong, China
Correspondence: [*] Corresponding authors: Hongbing Mei and Yuchen Liu, Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University Shenzhen 518035, Guangdong, China. E-mail:hbmei68@163.com,liuyuchenmdcg@163.com
Note: [1] Equal contributors.
Abstract: OBJECTIVE: In this study, we examined the relationships between the expression level of long non-coding RNA MIR31HG in bladder cancer and the clinical characteristics. METHODS: A total of 55 tissue samples from patients with bladder cancer were collected, and the lncRNA MIR31HG levels in cancer, paired non-cancer tissues and BC cell lines were detected by real-time quantitative RT-PCR (qRT-PCR). The relationships between MIR31HG level and the clinical characteristics were evaluated. RESULTS: MIR31HG expression was remarkably decreased in bladder cancer tissues compared with adjacent noncancerous tissues (P < 0.05). MIR31HG expression was also significantly down-regulated in four bladder cancer cell lines (P < 0.001). Clinicopathologic analysis revealed that MIR31HG expression was negatively associated with TNM stage (P = 0.010), but not with other clinicopathological characteristics. CONCLUSIONS: These findings revealed that MIR31HG may function as a cancer-suppressor gene to participate in the bladder cancer carcinogenesis and development.
Keywords: MIR31HG, LOC554202, bladder cancer, LncRNAs
DOI: 10.3233/CBM-160635
Journal: Cancer Biomarkers, vol. 17, no. 2, pp. 231-236, 2016
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