Affiliations: [a] Department of ENT, Linyi People's Hospital, Linyi, Shandong, China | [b] Linyi Women and Children's Hospital, Genetic Experiment Center, Linyi, Shandong, China
Correspondence:
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Corresponding author: Hua-Feng Li, Linyi Women and Children's Hospital, Genetic Experiment Center, Qinghe Nan Road No. 1, Luozhuang District, Linyi 276003, Shandong, China. Tel./Fax: +86 0539 3216138; E-mail:Lihuafeng0902@yeah.net
Abstract: Emerging evidence showed that functional polymorphisms in
the IL-10 gene may have effects on individuals' susceptibility to nasopharyngeal,
oral and esophageal cancers, yet individually published findings are
inconsistent. We therefore designed the meta-analysis to investigate the
correlations of IL-10 genetic polymorphisms with susceptibility to
nasopharyngeal, oral and esophageal cancers. The EMBASE, MEDLINE, CINAHL,
Web of Science and the Chinese Biomedical Database (CBM) databases were
searched with no language restrictions. We use Comprehensive Meta-analysis
2.0 software to carry out statistical analysis. Ten case-control studies
with a number of 1,883 patients and 2,857 healthy subjects were enrolled.
Our results revealed that IL-10 rs1800872 T>G and rs1800896 A>G
polymorphisms has a significantly association with the increased risk of esophageal
cancer under the allele and dominant models; rs1800871 T>G, rs1800872 T>G and
rs1800896 A>G under allele and dominant models could increase the risk of
nasopharyngeal cancer; rs1800871T>G, rs1800872T>G and rs1800896 A>G SNPs
under allele model were closely related to the susceptibility to oral
cancer. Our findings support the point that IL-10 genetic polymorphisms may play
essential role in identifying esophageal cancer, nasopharyngeal cancer and
oral cancer at early stage.
