Affiliations: [a] Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China | [b] Jining No.1 People's Hospital, Jining, Shandong, China
Correspondence:
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Corresponding author: Yang Jin, Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, Hubei, China. Tel.: +86 13554361146; Fax: +86 27 85755457; E-mail:whuhjy@126.com
Abstract: BACKGROUND: Lactare dehydrogenase (LDH) has been proven to be a
prognostic and a potential pro-tumor factor in patients with lung cancer.
But the prognostic value of serum LDH in small cell lung cancer (SCLC) has
not been quantified systematically. OBJECTIVE: Thus, this study was
to evaluate the correlations between serum LDH and overall survival of
SLCLC by systematic review with meta-analysis. METHODS: PubMed, EMBASE, Cochrane Library, Web of Science databases
were searched from inception to October 2014 and references in those
publications would be included if the association between serum LDH and
overall survival of SCLC can be derived. Quality assessment and data
extraction were performed in the articles selected according to inclusion
and exclusion criteria. RESULTS: Twenty-eight studies including 4785 patients with SCLC were deemed
eligible. Pooled results showed that SCLC patients with elevated LDH levels
were associated with an increased hazard ratio (HR 1.45, 95%CI 1.27∼
1.66) of overall survival. CONCLUSIONS: The study suggests significant correlations between
elevated serum LDH levels and poor overall survival in patients with SCLC.
And serum LDH levels can be measured combining with other tools for
assessing the risk stratification and prognosis of SCLC, which shows
directions for treatments of SCLC.
Keywords: Serum LDH levels, small cell lung cancer, prognosis, meta-analysis
