Overexpression of Cdc20 in clinically localized prostate cancer: Relation to high Gleason score and biochemical recurrence after laparoscopic radical prostatectomy
Affiliations: [a] Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China | [b] Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
Correspondence:
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Corresponding author: Xin Gao, Department of Urology, the Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou 510630, Guangdong, China. Tel.: +86 20 85252660; Fax: +86 20 85252678; E-mail:gaoxinmw@sina.com
Abstract: OBJECTIVES: This study was aimed to explore Cdc20 expression and
its correlation with clinicopathological characteristics and biochemical
recurrence (BCR) after laparoscopic radical prostatectomy (LRP) in
clinically localized prostate cancer (PCa). METHODS: Cdc20
expression was examined by immunohistochemistry in 166 cases, including 60
cases of benign hyperplasia of prostate (BPH) patients treated by
transurethral resection and 106 cases of consecutive PCa patients treated by
LRP without neoadjuvant therapy in a single Chinese institution. The
correlation with clinicopathological features and the predictive value for
BCR were statistically analyzed. RESULTS: Cdc20 expression was
detected in 52 (86.7%) BPH and 97 (91.5%) PCa samples, which was
statistically insignificant (P= 0.323). The rate of patients with high
expression of Cdc20 was 21.7% in BPH and 37.7% in PCa (P= 0.033). A
correlation was revealed between Cdc20 expression and postoperative Gleason
scores (P= 0.046), positive surgical margin (P< 0.001). BCR-free survival was
significantly lower in patients with high Cdc20 expression than those with
low Cdc20 expression (P= 0.018). Univariate analysis indicated pTstage, post
operative Gleason score, seminal vesicle invasion, lymph node invasion,
surgical margin and Cdc20 expression significantly influenced BCR.
Multivariate analysis revealed that postoperative Gleason score, seminal
vesicle invasion, lymph node invasion, surgical margin and Cdc20 expression
were independent predictors for BCR. After stratified by Gleason score and
surgical margin status, Cdc20 expression and lymph node invasion remained
significant in Cox regression analysis. CONCLUSIONS: Overexpression
of Cdc20 may serve as an independent predictor for BCR in patients of
clinically localized PCa undergoing LRP without neoadjuvant therapy.
