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Article type: Research Article
Authors: Li, Yongqinga | Xu, Yadongb | Yu, Chundongc | Zuo, Wenshua; *
Affiliations: [a] Breast Cancer Center, Shandong Cancer Hospital, Jinan, Shandong, China | [b] Department of the Second General Surgery, People's Hospital of Haiyang, Yantai, Shandong, China | [c] Department of Laboratory, Women and Children's Hospital of Qingdao, Qingdao, Shandong, China
Correspondence: [*] Corresponding author: Wenshu Zuo, Breast Cancer Center, Shandong Cancer Hospital, 440 Jiyan Road, Jinan, Shandong 250117, China. Tel.: +86 0531 87984777; Fax: +86 0532 87984079; E-mail:chenyingej@126.com
Abstract: BACKGROUND: MicroRNAs (miRNA) expression profiles might be useful novel biomarkers for tumor diagnostic and histological characterization. OBJECTIVE: Associations of miR-146 expression and breast cancer in very young women needed to be elucidated. METHODS: We investigated expressions of miR-146a, miR-146b and IL-6 in tissues between 120 young women with primary breast cancer and 130 patients with breast fibroadenoma by RT-PCR. The associations between the expression of miR-146, IL-6 and clinical parameters of breast cancer were analyzed. RESULTS: Levels of miR-146a and miR-146b in breast cancer tissues were lower while level of IL-6 was higher compared to the fibroadenoma tissues and pericancerous breast tissues (P< 0.05). Positive associations were found between levels of miR-146a/b and IL-6 in breast cancer tissues and ER-PgR-, HER2/neu-, Ki-67 index ≥ 20%, tumor size > 2 cm, positive distant metastasis and lymph node metastasis, advanced clinical TNM stages (III-IV) and basal-like phenotype (P< 0.05). CONCLUSION: Down-regulations of miR-146a and miR-146b expression in breast tissues were related to development and deterioration of breast cancer. miR-146a and miR-146b might act as potential biomarkers for young women with breast cancer.
Keywords: Breast cancer, miR-146a, miR-146b, RT-PCR
DOI: 10.3233/CBM-150532
Journal: Cancer Biomarkers, vol. 15, no. 6, pp. 881-887, 2015
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