Affiliations: [a] Department of Medical Oncology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong, China | [b] Department of General Surgery, Baiyun Lake Community Health Service Center of Baiyun District, Guangzhou, Guangdong, China | [c] Department of Gastrointestinal Surgery II, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong, China | [d] Department of ICU, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong, China | [e] Institute of Oncology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
Correspondence:
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Corresponding author: Xian-Zi Yang or Li-Si Zeng, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, 78 Hengzhigang Road, Yuexiu Region, Guangzhou 510095, Guangdong, China. Tel.: +86 20 6667 3666; Fax: +86 20 6667 3601; E-mail: yangxz@gzhmu.edu.cn or sisi713@163.com.
Note: [1] These authors contributed equally to this work.
Abstract: BACKGROUD/AIMS: LINC00323 is a novel lncRNA which has reported to play an important role in the development and recurrence in several cancers. However, the expression and predictive value of LINC00323 in gastric cancer (GC) remain mysterious. METHODS: LINC00323 expression in GC tissues and adjacent normal tissues was evaluated by quantitative reverse-transcription PCR (qRT-PCR). The relationship between LINC00323 expression and clinicopathological features and patients’ survival were analyzed. Univariate and multivariate survival analyses were performed. RESULTS: LINC00323 expression were found to be significantly increased in GC tissues. High expression of LINC00323 exerted a pro-tumor effect in the late stage of GC development. Kaplan-Meier analysis showed that patients with high LINC00323 were associated with poor overall survival (OS) and progression-free survival (PFS). Moreover, the combination of TNM stage and drinking status better identified GC patient outcome than those of TNM stage alone. CONCLUSIONS: Our data showed that LINC00323 overexpression might serve as a novel independent prognostic factor for survival of GC patients, suggesting LINC00323 was a potential biomarker and therapeutic target for GC.
