Affiliations: [a] Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China | [b] Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China | [c] Department of Endoscopy, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China | [d] Department of Interventional Medicine, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China
Correspondence:
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Corresponding authors: Zengyao Liu, Department of Interventional Medicine, The First Affiliated Hospital of Harbin Medical University, No. 23 Post Street, Nangang District, Harbin, Heilongjiang 150001, China. Tel.: +86 451 85555869; Fax: +86 451 85553575; E-mail: drliuzengyao@hrbmu.edu.cn. Ruitao Wang, Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, No.150 Haping ST, Nangang District, Harbin, Heilongjiang 150081, China. Tel.: +86 451 86298353; Fax: +86 451 86298352; E-mail: ruitao_wang@hrbmu.edu.cn.
Note: [1] Wen Wang and Guangyu Wang contributed equally to this work.
Abstract: BACKGROUND:Patients with microsatellite instability-high (MSI-H) colorectal cancer (CRC) generally have a better prognosis and a more effective immune response than patients with microsatellite stable (MSS) CRC. Moreover, activated platelets play a crucial role in modulating innate immune cells. Mean platelet volume (MPV) is an indicator of platelet activation. This study is to examine the association between MPV and MSI status in CRC. METHODS: We collected the clinical and pathological variables of 424 CRC patients diagnosed at the Harbin Medical University Cancer Hospital from January 2018 to December 2018. Associations between MPV levels and MSI status were examined. Propensity score matching (PSM) was performed to reduce the possibility of selection bias. RESULTS: 424 CRC patients were divided into low-MPV group and high-MPV group according to the optimal cut-off value of MPV. 131 high-MPV patients were matched to low-MPV counterparts in a 1:1 ratio by propensity score matching. As MPV levels increased, the percentage of patients with MSI-H reduced. Furthermore, compared with MSS group, the MSI-H group had a significantly lower MPV levels (p= 0.003 after matching). In addition, logistic regression analysis identified reduced MPV as an independent risk factor for MSI-H in CRC patients after controlling for other potential parameters. CONCLUSION: Lower MPV is associated with MSI-H subtype of CRC. Further study on MPV in MSI-H CRC is warranted.
Keywords: Colorectal cancer, microsatellite instability, platelet activation, mean platelet volume
