High expression of CPNE5 and CPNE9 predicts positive prognosis in multiple myeloma

Article type: Research Article

Authors: Zhu, Pei^{a; b; c; 1} | Qian, Tingting^{a; b; c; 1} | Si, Chaozeng^{d; 1} | Liu, Yan^{e; f} | Cui, Longzhen^{e; f} | Huang, Wenhui^{a; b; c} | Fu, Lin^{a; b; c; e; f; *} | Deng, Cong^{g; *} | Zeng, Tiansheng^{a; b; c; *}

Affiliations: [a] Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China | [b] Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China | [c] Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China | [d] Information Center, China-Japan Friendship Hospital, Beijing, China | [e] Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, Henan, China | [f] Department of Hematology, Huaihe Hospital of Henan University, Kaifeng, Henan, China | [g] Department of Clinical Laboratory, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China

Correspondence: [*] Corresponding authors: Lin Fu, Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China. E-mail: fulin022@126.com. Cong Deng, Department of Clinical Laboratory, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China. E-mail: cc_48@163.com. Tiansheng Zeng, Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China. E-mail: allenzengts@126.com.

Note: [1] These authors contributed equally to this work.

Abstract: BACKGROUND:CPNEs are significant biomarkers which can affect the progression and prognosis of various tumor diseases. However, the prognosis role of CPNEs in multiple myeloma (MM) is still unclear. OBJECTIVES: To investigate the prognosis role of CPNEs in MM. METHODS: Seven hundred and thirty-five samples from two independent data sets were involved to analyze the clinical and molecular characteristics, and prognosis role of the expression of CPNE1-9 in MM. RESULTS: MM patients with higher expressions of CPNE5 and CPNE9 had longer event-free survival (EFS) and overall survival (OS) compared with CPNE5low and CPNE9low expression groups (EFS: P= 0.0054, 0.0065; OS: P= 0.015, 0.016, respectively). Multivariate regression analysis showed that CPNE5 was an independent favorable predictor for EFS and OS (EFS: P= 0.005; OS: P= 0.006), and CPNE9 was an independent positive indicator for EFS (P= 0.002). Moreover, the survival probability and the cumulative event of EFS and OS in CPNE5highCPNE9high group were significantly longer than other groups. CONCLUSIONS: High expressions of CPNE5 and CPNE9 might be used as positive indicators for MM, and their combination was a better predictor for the survival of MM patients.

Keywords: Multiple myeloma, CPNE5, CPNE9, prognosis

DOI: 10.3233/CBM-203108

Journal: Cancer Biomarkers, vol. 31, no. 1, pp. 77-85, 2021