Affiliations: [a] Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, China | [b] Institute of Intensive Care Unit, Heilongjiang Academy of Medical Science, Harbin, Heilongjiang 150081, China | [c] Department of Intensive Care Unit, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, China
Correspondence:
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Corresponding authors: Kai-Jiang Yu, Department of Intensive Care Unit, Harbin Medical University Cancer Hospital, Harbin Medical University, No. 150 Haping ST, %****␣cbm-24-cbm192393_temp.tex␣Line␣100␣**** Nangang District, Harbin, Heilongjiang 150081, China. Tel.: +86 451 86298036; Fax: +86 451 86298036; E-mail: kaijiang_yu@yeah.net; Rui-Tao Wang. Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, NO.150 Haping ST, Nangang District, Harbin, Heilongjiang 150081, China. Tel.: +86 451 86298352; Fax: +86 451 86298353; E-mail: ruitaowang@126.com.
Note: [1] Ming-Ming Li and Xin Wang contributed equally to this work.
Abstract: BACKGROUND: Platelets play a crucial role in cancer progression and metastasis. The aim of the present study was to assess the relationship between platelet indices and non-small cell lung cancer (NSCLC) with brain metastases. METHODS: Between January 2015 and December 2017, 232 NSCLC patients with brain metastases and 244 NSCLC patients without metastases were retrospectively analyzed. Patients’ clinicopathological characteristics data were collected. RESULTS: Platelet count was increased and mean platelet volume (MPV) was reduced in NSCLC patients with brain metastases compared with NSCLC patients without metastases. In addition, the prevalence of NSCLC decreased as MPV quartiles increased. After adjusting for other risk factors, the ORs (95% CIs) for NSCLC brain metastases according to MPV quartiles were 1.757 (1.024–3.015), 2.097 (1.209–3.635), 1.517 (0.874–2.635), and 1.000, respectively. CONCLUSIONS: MPV is reduced in NSCLC patients with brain metastases compared with NSCLC patients without metastases. Moreover, MPV is found to be independently associated with the presence of NSCLC brain metastases.
Keywords: Non-small cell lung cancer, mean platelet volume, platelet activation
