Affiliations: [a] Department of Urology, Peking University First Hospital, Beijing, China | [b] Institute of Urology, Peking University, Beijing, China | [c] Capital Medical University, Beijing, China
Correspondence:
[*]
Corresponding author: Jian Lin, Department of Urology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China. Tel.: +86 138 0135 8465; Fax: +86 10 6655 1211; E-mail: linjianbj@163.com.
Note: [1] Contributed equally.
Abstract: Prolyl 4-hydroxylase, beta polypeptide (P4HB) protein has been found to be associated with tumorigenesis in many types of tumor, However, the relationship between P4HB and clear cell renal cell carcinoma (ccRCC) has not been clarified. In this study, we focus on the correlation between P4HB expression and ccRCC. Through the Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database, our database and immunohistochemical (IHC) staining. Compared with adjacent normal tissues, both the mRNA and protein levels of P4HB in ccRCC tissues were enhanced. The Kaplan-Meier survival analysis showed that high expression of P4HB is correlated with poor prognosis in both TCGA database and our own database. Multivariate survival analysis and Univariate analysis showed that P4HB expression and age are significantly correlative with poor prognose. All the results indicated that P4HB is correlated with poor prognosis in human clear cell renal cell carcinoma.
