Eukaryotic translation initiation factor 3B is overexpressed and correlates with deteriorated tumor features and unfavorable survival profiles in cervical cancer patients
Affiliations: [a] Department of Gynecology, The Affiliated Changzhou Matenity and Child Health Care Hospital of Nanjing Medical University, Changzhou, Jiangsu, China | [b] Department of Pathology, The Affiliated Changzhou Matenity and Child Health Care Hospital of Nanjing Medical University, Changzhou, Jiangsu, China | [c] Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
Correspondence:
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Corresponding authors: Lei Yuan, Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, 419 Fangxie Road, Shanghai 200011, China. Tel: +86 18964075180; E-mail: pingyao94412421@163.com; Peizhen Xu, Department of Gynecology, The Affiliated Changzhou Matenity and Child Health Care Hospital of Nanjing Medical University, 16 Boai Road, Changzhou, Jiangsu 213000, China. Tel: +86 13961183081; E-mail: fanqindunhhh@163.com.
Note: [1] Pengfeng Zhu and Qingqing Tan contributed equally to this work.
Abstract: OBJECTIVE: This study aimed to detect the expression of eukaryotic translation initiation factor 3B (EIF3B) and investigate its correlation with tumor features and survival in cervical cancer patients. METHODS: This study retrospectively reviewed 187 cervical cancer (squamous cell carcinoma) patients underwent tumor resection. Immunohistochemistry was performed to determine the expression of EIF3B in tissue samples. Besides, disease free survival (DFS) and overall survival (OS) were calculated. The median follow-up duration was 69 months, and the last follow-up date was 2017/12/31. RESULTS: EIF3B expression was higher in tumor tissue compared to paired adjacent tissue (45.5% vs. 32.1%, P= 0.015). Besides, EIF3B high expression was associated with higher Federation of Gynecology and Obstetrics (FIGO) Stage (P= 0.001) and presence of lymph node metastasis (P= 0.002). As to survival profiles, Kaplan-Meier curves disclosed that DFS (P< 0.001) and OS (P< 0.001) were both shorter in EIF3B high expression group compared to EIF3B low expression group. Multivariate Cox’s regression analysis disclosed that EIF3B high expression, pathological grade III (vs I/II) and FIGO Stage III/IV (vs I/II) were independent predictive factors for unfavorable DFS as well as OS in cervical cancer patients (all P value < 0.05). CONCLUSION: EIF3B is overexpressed, and its high expression correlates with higher FIGO Stage, lymph node metastasis and unfavorable survival profiles in cervical cancer patients.
